Sodium Azide → HCID 18625985, compound

HRID 1859984Notes

Reaction equation

HRID 1859984 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([CH3:31])([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)(=O)=O.[N-:32]=[N+:33]=[N-:34].[Na+]>>[N:32]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([CH3:31])([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)=[N+:33]=[N-:34]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 18625951HCID 18625951, compound

Product 1

HCID 18625985HCID 18625985, compoundYield 84.1%

Procedure

In a similar manner to that described in Reference example 3(h), a reaction was carried out using ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-methyl-2-(3-phenylpropyl)propionate (1.16 g), which is the product of Reference example 7(g), and sodium azide (0.50 g) and the reaction mixture was treated to afford the desired compound (0.86 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-070fa089c4db4b22a477b8335f4e744b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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