Dicyclohexylamine → HCID 12134925, compound

HRID 1859986Notes

Reaction equation

HRID 1859986 reaction equation
[O:1]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27]Cl)=[CH:25][CH:24]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C1(NC2CCCCC2)CCCCC1>>[CH2:15]([O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][C:8]([CH3:14])([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:25][CH:24]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7582DicyclohexylamineHCID 700424-Benzyloxybenzyl chlorideHCID 4496358HCID 4496358, compound

Product 1

HCID 12134925HCID 12134925, compoundYield 40.2%

Procedure

In a similar manner to that described in Reference example 7(c), a reaction was carried out using ethyl 2-phenoxypropionate (6.15 g), 4-benzyloxybenzyl chloride (9.62 g) and dicyclohexylamine (5.78 g) instead of diisopropylamine and the reaction mixture was treated to afford the desired compound (4.97 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-8563d1372b104d3ea210d74aac6a1437
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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