Sodium Azide → HCID 18625865, compound

HRID 1859998Notes

Reaction equation

[CH:1]([C:4]1[CH:32]=[CH:31][C:7]([O:8][C:9]([CH3:30])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24]OS(C)(=O)=O)=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[N-:33]=[N+:34]=[N-:35].[Na+]>>[N:33]([CH2:24][CH2:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][C:9]([O:8][C:7]2[CH:31]=[CH:32][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)([CH3:30])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:17][CH:18]=1)=[N+:34]=[N-:35]

Participants

Reactant 2

HCID 33557Sodium Azide

HCID 18625923HCID 18625923, compound

Product 1

HCID 18625865HCID 18625865, compoundYield 98.8%

Procedure

In a similar manner to that described in Reference example 3(h), a reaction was carried out using ethyl 2-(4-isopropylphenoxy)-3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-methylpropionate (0.64 g), which is the product of Reference example 9(e), and sodium azide (0.27 g) and the reaction mixture was treated to afford the desired compound (0.56 g) as a syrup.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-5c1a4cc8d6d14a0ca2f140562fac36a5
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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