HCID 18625865, compound → HCID 18625934, compound

HRID 1859999Notes

Reaction equation

HRID 1859999 reaction equation
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:21][C:22]2[CH:27]=[CH:26][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=2)([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=1)=[N+]=[N-]>[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:21][C:22]2[CH:23]=[CH:24][C:25]([CH:28]([CH3:29])[CH3:30])=[CH:26][CH:27]=2)([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 18625865HCID 18625865, compound

Product 1

HCID 18625934HCID 18625934, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-[4-(2-azidoethoxy)phenyl]-2-(4-isopropylphenoxy)-2-methylpropionate (0.56 g), which is the product of Reference example 9(f), and palladium on carbon (5%, 60 mg) and the reaction mixture was treated to afford the title compound (0.51 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-9b7eb351f497433f86d34ee706794fe0
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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