p-Toluenesulfonic acid monohydrate → Ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]-2-methylpropionate

Participants

Reaction Steps

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-butyl-2-methyl-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate (4.18 g), which is the product of Reference example 10(c), and p-toluenesulfonic acid monohydrate (2.61 g) and the reaction mixture was treated to afford the desired compound (2.73 g) as a syrup.

Provenance & Evidence