Sodium Hydroxide → 4'-Dimethoxymethylbiphenyl-4-carboxylic acid

HRID 1860008Notes

Reaction equation

HRID 1860008 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[OH-].[Na+]>>[CH3:21][O:20][CH:3]([O:2][CH3:1])[C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625704Methyl 4'-dimethoxymethylbiphenyl-4-carboxylate

Product 1

HCID 186256964'-Dimethoxymethylbiphenyl-4-carboxylic acidYield 100.1%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 4′-dimethoxymethylbiphenyl-4-carboxylate (1.89 g), which is the product of Reference example 11(a), and aqueous sodium hydroxide (1N, 9.90 ml) and the reaction mixture was treated to afford the desired compound (1.80 g) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-082edb70c69f4c4d9be86f4b0f653062
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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