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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1860009Generated: November 1, 2026

1,1'-Carbonyldiimidazole → Ethyl 2-butyl-3-[4-[2-(4'-methoxycarbonylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

https://huagongshe.com/reaction/1860009

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
Reactant4-[4-(Methoxycarbonyl)phenyl]benzoic acidHCID 14250826—
ReactantEthyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionateHCID 18625891—
ProductEthyl 2-butyl-3-[4-[2-(4'-methoxycarbonylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionateHCID 1862604437.8%

Reaction Steps

In a similar manner to that described in Example 5, a reaction was carried out using ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionate (375 mg), which is the product of Reference example 6, 4′-methoxycarbonylbiphenyl-4-carboxylic acid (328 mg) and carbonyldiimidazole (225 mg) and the reaction mixture was treated to afford the title compound (257 mg) as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06528525B1
Source datasetuspto-grants-2003_03
ORD IDord-645ddc704ac645fdb85fd4555a75424f
Source noteuspto-grants-2003_03