Sodium Hydroxide → 3'-Dimethoxymethylbiphenyl-4-carboxylic acid

HRID 1860013Notes

Reaction equation

HRID 1860013 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1.[OH-].[Na+]>>[CH3:21][O:20][CH:3]([O:2][CH3:1])[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18626005HCID 18626005, compound

Product 1

HCID 186258743'-Dimethoxymethylbiphenyl-4-carboxylic acidYield 85.3%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3′-dimethoxymethylbiphenyl-4-carboxylate (1.91 g), which is the product of Reference example 14(b), and aqueous sodium hydroxide (1N, 10.0 ml) and the reaction mixture was treated to afford the desired compound (1.55 g) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-7b122282a3904a01a107eec63ab3478a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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