Sodium Hydroxide → 2-Butyl-3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid

HRID 1860023Notes

Reaction equation

HRID 1860023 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[C:34]([CH3:36])[C:33]([O:37][CH2:38][O:39][CH3:40])=[C:32]([CH3:41])[CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:31]=[C:32]([CH3:41])[C:33]([O:37][CH2:38][O:39][CH3:40])=[C:34]([CH3:36])[CH:35]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625993Ethyl 2-butyl-3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

Product 1

HCID 186260132-Butyl-3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acidYield 104.2%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using ethyl 2-butyl-3-[4-[2-(4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (1.01 g), which is the product of Reference example 17(c) and aqueous sodium hydroxide solution (1N, 3.60 ml) and the reaction mixture was treated to afford the title compound (1.00 g) as a foam powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-bcbf788923164552a5de7c039430c4e1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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