Sodium Azide → HCID 18625767, compound

HRID 1860028Notes

Reaction equation

HRID 1860028 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21]OS(C)(=O)=O)=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4].[N-:27]=[N+:28]=[N-:29].[Na+]>>[N:27]([CH2:21][CH2:20][CH2:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:13][CH:14]=1)=[N+:28]=[N-:29]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 18625784HCID 18625784, compound

Product 1

HCID 18625767HCID 18625767, compoundYield 95.3%

Procedure

In a similar manner to that described in Reference example 3(h), a reaction was carried out using ethyl 2-butyl-3-[4-(3-methanesulfonyloxypropoxy)phenyl]propionate (2.98 g) and sodium azide (1.50 g) and the reaction mixture was treated to afford the desired compound (2.45 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-1e02c0f13de94a4c844029d64fc3d59b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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