HCID 18625767, compound → HCID 18626001, compound

HRID 1860029Notes

Reaction equation

HRID 1860029 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH2:21][CH2:22][CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=1)=[N+]=[N-]>[Pd]>[NH2:1][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH2:21][CH2:22][CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 18625767HCID 18625767, compound

Product 1

HCID 18626001HCID 18626001, compoundYield 71.7%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-[4-(3-azidopropoxy)phenyl]-2-butylpropionate (2.45 g) and palladium on carbon (5%, 250 mg) and the reaction mixture was treated to afford the desired compound (1.62 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-3f50e76a790b4f11bac5f6dfbe5d1e86
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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