Sodium Hydroxide → 3-[4-[2-(4'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acid

HRID 1860035Notes

Reaction equation

HRID 1860035 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([O:34]CC)=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH3:44].[OH-].[Na+]>>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([OH:34])=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:16][CH:17]=2)=[CH:7][C:6]=1[CH3:44]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625980Ethyl 3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate

Product 1

HCID 186259463-[4-[2-(4'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acidYield 75.8%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using ethyl 3-[4-[2-(4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (720 mg), which is the product of Reference example 24(a) and aqueous sodium hydroxide (1N, 2.40 ml) and the reaction mixture was treated to afford the title compound (520 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-14ca1fff39d44d62afc110dc565d96bb
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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