HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-(4-Fluorophenyl)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-(4-Fluorophenyl)pyridine-3-carboxylic acid methyl ester | HCID 11031712 | — |
| Product | 6-(4-Fluorophenyl)nicotinic acid | HCID 22730186 | 94.2% |
Reaction Steps
In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-fluorophenyl)nicotinate (390 mg) and aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to afford the title compound (345 mg) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528525B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-e68c8e300c7a42e58d9cf95081c2c404 |
| Source note | uspto-grants-2003_03 |