HCID 69876145, compound → HCID 69875371, compound

HRID 1860047Notes

Reaction equation

HRID 1860047 reaction equation
[CH2:1]([C@@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:42])[C@H:15]([O:32][C:33]1[CH:38]=[CH:37][C:36]([CH:39]([CH3:41])[CH3:40])=[CH:35][CH:34]=1)[C@H:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24]CC2C=CC=CC=2)=[CH:20][CH:19]=1)[OH:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([C@@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:42])[C@H:15]([O:32][C:33]1[CH:38]=[CH:37][C:36]([CH:39]([CH3:40])[CH3:41])=[CH:35][CH:34]=1)[C@@H:16]([OH:17])[C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 69876145HCID 69876145, compound

Product 1

HCID 69875371HCID 69875371, compoundYield 98.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using (R)-4-benzyl-3-[(2R,3S)-3-(4-benzyloxyphenyl)-3-hydroxy-2-(4-isopropylphenoxy)propionyl]oxazolidine-2-one (9.00 g), which is the product of Reference example 30(b) and palladium on carbon (5%, 1.80 g) and the reaction mixture was treated to afford the desired compound (7.48 g) as a mass of foam.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-567fe967843e4b40bab744b77fbf96b4
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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