Sodium Hydroxide → HCID 18625820, compound

HRID 1860057Notes

Reaction equation

HRID 1860057 reaction equation
[CH3:1][N:2]([CH3:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([O:13]C)=[O:12])=[CH:7][CH:8]=1.[OH-].[Na+]>>[CH3:1][N:2]([CH3:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([OH:13])=[O:12])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625803HCID 18625803, compound

Product 1

HCID 18625820HCID 18625820, compoundYield 90.5%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3-dimethylaminopyridine-6-ylbenzoate (277 mg), which is the product of Reference example 34(a), and aqueous sodium hydroxide solution (1N, 2.20 ml) and the reaction mixture was treated to afford the title compound (237 mg)as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e5fa627cdc5b4b7d93d960368821afb6
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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