HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-tert-Butylphenol → Ethyl 3-(4-benzyloxyphenyl)-2-(4-t-butylphenoxy)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-tert-Butylphenol | HCID 7393 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | 3-(4-Benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester | HCID 15186153 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 3-(4-benzyloxyphenyl)-2-(4-t-butylphenoxy)propionate | HCID 18625918 | 41.7% |
Reaction Steps
In a similar manner to that described in Example 122, a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)lactate (5.00 g), which is the product of Reference example 1(b), 4-t-butylphenol (2.50 g), triphenylphosphine (5.24 g) and a solution of diethylazodicarboxylate in toluene (40%, 8.80 ml) and the reaction mixture was treated to afford the desired compound (3.00 g) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528525B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-e8b707fdd6b847079ec6a7634d360a89 |
| Source note | uspto-grants-2003_03 |