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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1860062Generated: November 1, 2026

4-tert-Butylphenol → Ethyl 3-(4-benzyloxyphenyl)-2-(4-t-butylphenoxy)propionate

https://huagongshe.com/reaction/1860062

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-tert-ButylphenolHCID 7393—
ReactantTriphenylphosphineHCID 11776—
ReactantDiethyl azodicarboxylateHCID 5462977—
Reactant3-(4-Benzyloxyphenyl)-2-hydroxypropionic acid ethyl esterHCID 15186153—
SolventTolueneHCID 1140—
ProductEthyl 3-(4-benzyloxyphenyl)-2-(4-t-butylphenoxy)propionateHCID 1862591841.7%

Reaction Steps

In a similar manner to that described in Example 122, a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)lactate (5.00 g), which is the product of Reference example 1(b), 4-t-butylphenol (2.50 g), triphenylphosphine (5.24 g) and a solution of diethylazodicarboxylate in toluene (40%, 8.80 ml) and the reaction mixture was treated to afford the desired compound (3.00 g) as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06528525B1
Source datasetuspto-grants-2003_03
ORD IDord-e8b707fdd6b847079ec6a7634d360a89
Source noteuspto-grants-2003_03