Sodium Azide → HCID 18625882, compound

HRID 1860070Notes

Reaction equation

HRID 1860070 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22]OS(C)(=O)=O)=[CH:16][CH:15]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.[N-:30]=[N+:31]=[N-:32].[Na+]>>[N:30]([CH2:22][CH2:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH:7]([O:6][C:5]2[CH:28]=[CH:29][C:2]([F:1])=[CH:3][CH:4]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:15][CH:16]=1)=[N+:31]=[N-:32]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 18625859HCID 18625859, compound

Product 1

HCID 18625882HCID 18625882, compoundYield 96.5%

Procedure

In a similar manner to that described in Reference example 3(h), a reaction was carried out using ethyl 2-(4-fluorophenoxy)-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionate (3.16 g), which is the product of Reference example 37(e), and sodium azide (1.45 g) and the reaction mixture was treated to afford the desired compound (2.67 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-d3781dbea8044603b8a1e1477451f75c
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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