HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate → Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate | HCID 18625730 | — |
| Reactant | 4-(2-Pyridinyl)benzoyl Chloride Hydrochloride | HCID 18625910 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate | HCID 18625968 | 91% |
Reaction Steps
In a similar manner to that described in Example 126, a reaction was carried out using ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate (168 mg), 4-pyridine-2-ylbenzoylchloride hydrochloride (126 mg) and triethylamine (0.28 ml) and the reaction mixture was treated to afford the title compound (188 mg) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528525B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-ddbc3c231a354e7d9245f9d85f3efe5f |
| Source note | uspto-grants-2003_03 |