HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-(4-cyanophenoxy)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2-(4-cyanophenoxy)-3-(4-hydroxyphenyl)propionate | HCID 18625868 | — |
| Reactant | tert-Butyl N-(2-((methylsulfonyl)oxy)ethyl)carbamate | HCID 22605302 | — |
| Product | Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-(4-cyanophenoxy)propionate | HCID 18625774 | 57.3% |
Reaction Steps
In a similar manner to that described in Reference example 25, a reaction was carried out using ethyl 2-(4-cyanophenoxy)-3-(4-hydroxyphenyl)propionate (293 mg), t-butyl 2-methanesulfonyloxyethylcarbamate (560 mg) and potassium carbonate (520 mg) and the reaction mixture was treated to afford the title compound (245 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528525B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-16ba483dccca4ca5a71c7d3e254b8c5b |
| Source note | uspto-grants-2003_03 |