Triphenylphosphine → Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)-3-chlorophenyl]-2-phenoxypropionate

Participants

Reaction Steps

In a similar manner to that described in Example 122, a reaction was carried out using ethyl 3-(3-chloro-4-hydroxyphenyl)-2-phenoxypropionate (761 mg), which is the product of Reference example 51(a), t-butyl 2-hydroxyethylcarbamate (0.96 g), triphenylphosphine (1.55 g) and solution of diethylazodicarboxylate in toluene (40%, 2.69 ml) and the reaction mixture was treated to afford the desired compound (1.03 g) as a colorless oil.

Provenance & Evidence