HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Ethyl 3-[3-bromo-4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-phenoxypropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | tert-butyl N-(2-hydroxyethyl)carbamate | HCID 2733206 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | Ethyl 3-(3-bromo4-hydroxyphenyl)-2-phenoxypropionate | HCID 18625875 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 3-[3-bromo-4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-phenoxypropionate | HCID 18626002 | 89.5% |
Reaction Steps
In a similar manner to that described in Example 122, a reaction was carried out using ethyl 3-(3-bromo-4-hydroxyphenyl)-2-phenoxypropionate (374 mg), which is the product of Reference example 52(a), t-butyl 2-hydroxyethylcarbamate (403 mg), triphenylphosphine (672 mg) and a solution of diethylazodicarboxylate in toluene (40%, 1.16 ml) and the reaction mixture was treated to afford the desired compound (466 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528525B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-15be501d351b498db78689d6f6c77635 |
| Source note | uspto-grants-2003_03 |