Caffeic Acid → HCID 22976143, compound

Participants

Reaction Steps

The title compound was prepared from N-[Nα-(tert-butoxycarbonyl)-O-benzyl-L-threonyl]dopamine (1.0 g, 2.3 mmol, example 9, step A) as described for example 9 (step B) using caffeic acid (620 mg, 3.4 mmol) instead of 3,4-dihydroxybenzoic acid. The crude material was purified by flash chromatography using 30% EtOAc/CHCl3 and 5% MeOH/CHCl3 as the eluent. The title compound was obtained as yellow crystals (717 mg, 62%).

Provenance & Evidence