HRID1860328

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID689043

trans-Caffeic acid

C9H8O4

结构：CNC(=O)CC[C@@H](C(=O)NCc1ccc(O)c(O)c1)N(C(=O)OCC1c2ccccc2-c2ccccc21)C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID22976126

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)CC[C@@H](C(=O)NCc1ccc(O)c(O)c1)N(C(=O)/C=C/c1ccc(O)c(O)c1)C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID22976139

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-[Nα-(9-fluorenylmethoxycarbonyl)-Nδ-methyltrityl-L-glutaminyl]-3,4-dihydroxybenzylamine (900 mg, 1.2 mmol, example 26, step A) as described for example 26 (step B) using caffeic acid (326 mg, 1.8 mmol) instead of 4-hydroxy-3-nitrobenzoic acid. The crude material was purified by flash chromatography using a solvent gradient from 30% to 70% EtOAc/CH2Cl2/1% AcOH. The title compound was obtained as a yellow powder (430 mg, 52%).

WORKUP

后处理

customThe crude material was purified by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4391a4214b974724b8caedc470a317a7
来源数据集: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06528655B1
来源说明: uspto-grants-2003_03

反应 SMILES

C1C2C(CO[C:16]([N:18]([C:38]([C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)[C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C@H:19]([C:26]([NH:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([OH:36])=[C:32]([OH:37])[CH:31]=3)=[O:27])[CH2:20][CH2:21][C:22](=[O:25])[NH:23][CH3:24])=[O:17])C3C(=CC=CC=3)C=2C=CC=1.C(O)(=O)/[CH:58]=[CH:59]/[C:60]1[CH:67]=[CH:66][C:64]([OH:65])=[C:62]([OH:63])[CH:61]=1>>[C:16]([N:18]([C:38]([C:51]1[CH:52]=[CH:53][CH:54]=[CH:55][CH:56]=1)([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)[C@H:19]([C:26]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[C:32]([OH:37])[CH:31]=1)=[O:27])[CH2:20][CH2:21][C:22](=[O:25])[NH:23][CH3:24])(=[O:17])/[CH:58]=[CH:59]/[C:60]1[CH:67]=[CH:66][C:64]([OH:65])=[C:62]([OH:63])[CH:61]=1