HRID1860331

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID114578

3-(2,5-Dimethoxyphenyl)-2-propenoic acid

C11H12O4

结构：CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCc1ccc(O)c(O)c1

HCID22976135

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OC)c(C=CC(=O)N[C@@H](COC(C)(C)C)C(=O)NCCc2ccc(O)c(O)c2)c1

HCID504809

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-[Nα-(9-fluorenylmethoxycarbonyl)-O-tert-butyl-L-seryl]dopamine (572 mg, 1.1 mmol, example 42, step A) as described for example 42 (step B) using 2,5-dimethoxycinnamic acid (345 mg, 1.7 mmol) instead of caffeic acid. The crude material was purified by flash chromatography using 10% EtOAc/CH2Cl2/1% AcOH and 50% EtOAc/CH2Cl2 as the eluent. The title compound was obtained as a yellow powder (300 mg, 56%).

WORKUP

后处理

customThe crude material was purified by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1acbf86edf554d15b263eb2bd0ce5434
来源数据集: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06528655B1
来源说明: uspto-grants-2003_03

反应 SMILES

C1C2C(CO[C:16]([NH:18][C@H:19]([C:26]([NH:28][CH2:29][CH2:30][C:31]3[CH:38]=[CH:37][C:35]([OH:36])=[C:33]([OH:34])[CH:32]=3)=[O:27])[CH2:20][O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:17])C3C(=CC=CC=3)C=2C=CC=1.[CH3:39][O:40][C:41]1[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[CH:48][C:42]=1[CH:43]=[CH:44]C(O)=O>>[CH3:39][O:40][C:41]1[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[CH:48][C:42]=1[CH:43]=[CH:44][C:16]([NH:18][C@H:19]([C:26]([NH:28][CH2:29][CH2:30][C:31]1[CH:38]=[CH:37][C:35]([OH:36])=[C:33]([OH:34])[CH:32]=1)=[O:27])[CH2:20][O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:17]