2-Propenoic acid, 3-(3-nitrophenyl)- → HCID 86758868, compound

Participants

Reaction Steps

This compound was prepared from N-[Nα-(9-fluorenylmethoxycarbonyl)-Nδ-methyltrityl-L-glutaminyl]dopamine (628 mg, 0.8 mmol, example 48, step A) as described for example 48 (step B) using 3-nitrocinnamic acid (240 mg, 1.2 mmol) instead of caffeic acid. The crude material was purified by flash chromatography using successively 15%, 20% and 35% EtOAc/CH2Cl2/1% AcOH as the eluent. The title compound was obtained as a yellow powder (247 mg, 42%).

Provenance & Evidence