Caffeic Acid → HCID 22976138, compound

Participants

Reaction Steps

N-[Nα-(9-fluorenylmethoxycarbonyl)-Nδ-butoxycarbonyl-L-ornithyl]dopamine (1.0 g, 1.75 mmol) was deprotected following the indications of general procedure G. The free amino groups thus obtained were coupled with caffeic acid (472 mg, 2.6 mmol) following the general procedure D. The crude material was purified by flash chromatography using a solvent gradient from 30% to 90% EtOAc/CH2Cl2/1% AcOH. The desired product was obtained as white crystals (370 mg, 40%).

Provenance & Evidence