N-[Nalpha-(9-fluorenylmethoxycarbonyl)-Ndelta-methyltrityl-L-glutaminyl]-3,4-dihydroxybenzylamine → HCID 178485711, compound

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Reaction Steps

The title compound was prepared from N-[Nα-(9-fluorenylmethoxycarbonyl)-Nδ-methyltrityl-L-glutaminyl]-3,4-dihydroxybenzylamine (1.0 g, 1.4 mmol, example 26, step A) as described for example 26 using 4,8-dihydroxyquinoline-2-carboxylic acid (435 mg, 2.1 mmol) instead of4-hydroxy-3-nitrobenzoic acid. The crude material was purified by flash chromatography using a solvent gradient from 30% to 60% EtOAc/CH2Cl2/1% AcOH. The title compound was obtained as yellow crystals (100 mg, 10%).

Provenance & Evidence