2-Amino-4-methylpyridine → N-(4-Methyl-2-pyridyl)acetamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-amino-4-methylpyridine (20 g) in acetic acid (80 ml) was added acetic anhydride and the resulting solution was refluxed for 3 h. The solution was concentrated in vacuo and the solid obtained was triturated with about 50 ml of water and carefully neutralised with solid sodium bicarbonate. The solid was filtered, washed with water and dried under vacuum to give the crude title compound as a white solid (20 g).

Herkunft & Nachweise