Phosphoric Acid → HCID 136201556, compound

HRID 1860431Notes

Reaction equation

HRID 1860431 reaction equation
[C:1]([C:3]1[CH:7]=[C:6]([CH3:8])[N:5]([C:9]2[C:14]([CH3:15])=[CH:13][C:12]([CH3:16])=[CH:11][C:10]=2[CH3:17])[C:4]=1[NH:18][C:19](=O)[CH3:20])#[N:2].P(=O)(O)(O)[OH:23]>>[CH3:20][C:19]1[NH:2][C:1](=[O:23])[C:3]2[CH:7]=[C:6]([CH3:8])[N:5]([C:9]3[C:14]([CH3:15])=[CH:13][C:12]([CH3:16])=[CH:11][C:10]=3[CH3:17])[C:4]=2[N:18]=1

Participants

3

Reactant 2

HCID 1004Phosphoric AcidHCID 18623789HCID 18623789, compound

Product 1

HCID 136201556HCID 136201556, compoundYield 67%

Conditions

Temperature
130 °C

Procedure

A mixture of compound (4) (32.1 g, 0.144 mol) and 85% phosphoric acid (30 mL) was heated at 130° C. for 30 minutes. The resulting mixture was cooled to room temperature, poured into ice water with vigorous stirring, and the resulting precipitate was filtered and dried under vacuum to afford 21.6 g (67%) of compound (5) as a pink solid.

Workup

  1. temperatureThe resulting mixture was cooled to room temperature
  2. filtrationthe resulting precipitate was filtered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-c1c8b4e1ff474f22b53114c37facbed6
Source dataset
uspto-grants-2003_03
Patent number
US06531475B1

Reaction notes

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