HCID 18623810, compound → HCID 18623791, compound

Participants

Reaction Conditions

Reaction Steps

32.3 g (71 mmol) of 1,4-dibenzyl-2-isopropyloxycarbonylaminomethylpiperazine hydrochloride are dissolved in 100 ml of acetic acid and 200 mg of palladium (10%) on charcoal are added. Using PARR apparatus, the suspension is stirred and heated at 60° C. under hydrogen pressure (2.7 bar) overnight. The catalyst is filtered off and the solvent is evaporated to give a compound which is crystallized from an ethanol/ether mixture (5/95 v/v) to give 17 g of 2-isopropyloxycarbonylaminomethylpiperazine hydrochloride in the form of white crystals. Yield: 87%. Melting point: 237.1° C. Rf=0.6 (80/20/2 v/v/v CHCl3/MeOH/NH4OH).

Provenance & Evidence