反应详情

Ditoluoyl-D-tartaric acid (5.033 g, 12.4 mmol) was suspended in a solution of 2% methanol in acetone (10 ml), and a solution of threo-methylphenidate (2.9 g, 12.4 mmol) in the same solvent (10 ml) was added. The solution was gently warmed to reflux whereupon all the reagents dissolved. The solution was immediately cooled and crystals began to form. The solution was allowed to stand at 4° C. for 17 hours and was then filtered. The crystals were washed with acetone (3×15 ml) and dried in vacuo to yield the ditoluoyl-D-tartrate salt of d-threo methylphenidate (3.516 g, 44.3% by weight; corresponding to 97% ee d-threo methylphenidate, as determined by chiral HPLC after salt cracking). The mother liquors were dried in vacuo to yield the ditoluoyl-D-tartrate salt of l-threo-methylphenidate as a solid, dry form (4.508 g, 50.5% yield, 88% ee).

1. temperatureThe solution was gently warmed
2. temperatureto reflux whereupon all the reagents
3. dissolutiondissolved
4. temperatureThe solution was immediately cooled
5. customto form
6. filtrationwas then filtered
7. washThe crystals were washed with acetone (3×15 ml)
8. customdried in vacuo