HCID 70005765, compound → HCID 54404731, compound

Participants

Reaction Steps

A mixture of trans-7-[2-(3-naphthalen-1-yl-3-oxo-propenyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester of Step A (143 mg, 0.352 mmol), 10% palladium on carbon (100 mg), and ethyl acetate (10 mL) were hydrogenated on a Parr shaker at 50 psi for 1.5 h. The catalyst was removed via filtration through Celite®. The filtrate was concentrated and the residue was purified by radial chromatography (hexanes to 25% ethyl acetate in hexanes) to provide the title compound of Step B (100 mg) as a clear and colorless oil. MS 426 (M+18).

Provenance & Evidence