Hydrochloric Acid → HCID 54396317, compound

Participants

Reaction Steps

To a solution of 6-(2-oxo-cyclopentylidene)-heptanoic acid methyl ester obtained in Step B in methanol (1000 mL) was added concentrated hydrochloric acid (100 mL) and the reaction was heated at reflux for 20 h. The reaction mixture was cooled and was diluted with ethyl acetate. The organic solution was neutralized with aqueous sodium bicarbonate, dried (magnesium sulfate), filtered, and concentrated. Purification by distillation (145-155° C. at about 0.2 mmHg) provided 40 g of the title compound of Step C. 1H NMR (CDCl3, 250 MHz) d 7.28 (m, 1H), 3.65 (s, 3H), 2.54 (t, 2H), 2.38 (m, 2H), 2.28 (t, 2H), 2.14 (m, 2H), 1.61 (m, 2H), 1.45 (m, 2H), 1.31 (m, 4H).

Provenance & Evidence