Hydrochloric Acid → HCID 70006814, compound

Participants

Reaction Conditions

Reaction Steps

Potassium dihydrogen phosphate (4.6 g, 33.44 mmol) was dissolved in deionized water (0.5 L), and was brought to pH 7 using sodium hydroxide solution (2M). To this was added Candida Cyclridraceae (400 mg). The solution was warmed to 37-40° C., and trans-7-[2-oxo-5-(2-tributylstannanyl-vinyl)-cyclopentyl]-heptanoic acid methyl ester of Step D (3.00 g, 13.38 mmol) was added with vigorous stirring. After 4 h, concentrated hydrochloric acid was added to bring the pH to 1 and the solution was extracted with ethyl acetate. The organic phase was dried, and the solvent was removed in vacua to yield the title compound as a yellow syrup.

Provenance & Evidence