Hydrochloric Acid → 2-Hydrazino-5-(methylsulfonyl)pyridine hydrochloride

HRID 1860600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1860600
CS([C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][N:6]=1)(=O)=O.[NH2:15][NH2:16].[ClH:17]>C(O)C>[ClH:17].[NH:15]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][N:6]=1)[NH2:16]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 131026752,5-Bis(methylsulfonyl)pyridine

Produkt 1

HCID 222268132-Hydrazino-5-(methylsulfonyl)pyridine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The 2,5-bis-methanesulfonyl-pyridine and anhydrous hydrazine are stirred in ethanol for two hours between room temperature and reflux temperature. After cooling to room temperature the mixture is concentrated. The residual solid is washed with aqueous saturated NaHCO3 and water and collected by filtration to give a pale yellow solid. The solid is treated with 10% methanolic HCl and the precipitate is collected by filtration to give the title compound.

Aufarbeitung

  1. temperaturereflux temperature
  2. concentrationis concentrated
  3. washThe residual solid is washed with aqueous saturated NaHCO3 and water
  4. filtrationcollected by filtration
  5. customto give a pale yellow solid
  6. filtrationthe precipitate is collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b4a8ef2183f648a2910442f2f801db97
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06531492B1

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