Sodium Hydroxide → HCID 12017315, compound

HRID 1860632Notes

Reaction equation

HRID 1860632 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[N:14]=[C:13]([CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C:25]([CH3:32])([CH3:31])[CH2:26][C:27]([O:29]C)=[O:28])=[CH:20][CH:19]=2)[CH:12]=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO.O>[C:1]([O:5][C:6]([NH:8][C:9]1[N:14]=[C:13]([CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C:25]([CH3:32])([CH3:31])[CH2:26][C:27]([OH:29])=[O:28])=[CH:20][CH:19]=2)[CH:12]=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 12018747HCID 12018747, compound

Product 1

HCID 12017315HCID 12017315, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of the product of STEP 7 (0.5 g) in methanol (2 mL) and a solution of NaOH (1 g) in water (6 mL) was heated to reflux for 30 minutes. The mixture was cooled to 0° C., acidified to pH=4 and extracted with ethyl acetate. The extract was dried over MgSO4 and concentrated in vacuo to provide the above product as a white solid.

Workup

  1. temperatureto reflux for 30 minutes
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6e3168ce865b40b9b36ace2bda1341d9
Source dataset
uspto-grants-2003_03
Patent number
US06531494B1

Reaction notes

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