Bromine → HCID 18624189, compound

Participants

Reaction Steps

Bromine solution (12.4 ml, 12.4 mmol, 1.0 M in CCl4) was added a solution of the product of STEP 6 (1.58 g, 6.2 mmol) in 30 ml CCl4 at 0° C. over 5 min. The reaction was stirred at room temperature for 30 min, and quenched with saturated NaHCO3 solution. The product was extracted with ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed brine, dried with Na2SO4, and concentrated. The residue was purified by chromatography (on silica gel, ethyl acetate/ hexane=1/9) to give a colorless oil in 0.73 g. NMR spectra of the product were consistent for the proposed structure.

Provenance & Evidence