4-Methylmorpholine → HCID 12018738, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the product of STEP 8 (0.725 g, 1.24 mmol), 4-methylmorpholine (1.01 g, 10 mmol), and 2-fluoropyridine (10 ml) was heated at 115° C. for 18 h under N2. The cooled reaction was concentrated. The residue was purified by chromatography (on silica gel, CH2Cl2/CH3OH/NH4OH=97/2/1) to give a brown oil in 0.251 g. NMR spectra of the product were consistent for the proposed structure.

Provenance & Evidence