Triphenylphosphine → HCID 178471300, compound

Participants

Reaction Steps

A solution of diethyl azodicarboxylate (157 mg, 0.9 mmol) in 2 ml THF was added to a solution of the product of STEP 7 (197 mg, 0.66 mmol) and triphenylphosphine (236 mg, 0.9 mmol) in 5 ml THF at room temperature and stirred for 15 min. 2-(3-Hydroxypropylamino)pyridine N-oxide (168 mg, 0.9 mmol) was added. The reaction was stirred at room temperature for 18 h. THF was evaporated and the residue was purified by chromatography (on silica gel, CH2Cl2/CH3OH/NH4OH-98.5/1/0.5) to afford a clean product in 154 mg. NMR spectra of the product were consistent for the proposed structure.

Provenance & Evidence