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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1860873Generated: October 25, 2026

N-methyl-2-oxoindoline-5-sulfonamide → 2-Methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester

https://huagongshe.com/reaction/1860873

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methyl-2-oxoindoline-5-sulfonamideHCID 10176909—
Reactant5-formyl-2-methyl-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic acid ethyl esterHCID 53770915—
Product2-Methyl-5-(5-methylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic Acid Ethyl EsterHCID 53840181—

Reaction Steps

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide was stirred with 5-formyl-2-methyl-4-(3-morpholin-4-ylpropyl)-1H-pyrrole-3-carboxylic acid ethyl ester overnight at room temperature to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06531502B1
Source datasetuspto-grants-2003_03
ORD IDord-67de66783e174f31af104e719463ea27
Source noteuspto-grants-2003_03