N-methyl-2-oxoindoline-5-sulfonamide → HCID 69770172, compound

HRID 1860874Notes

Reaction equation

HRID 1860874 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[CH2:16]([O:18][C:19]([C:21]1[C:25]([CH2:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[C:24]([CH:32]=O)[NH:23][C:22]=1[CH3:34])=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[C:25]([CH2:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[C:24]([CH:32]=[C:9]2[C:8]3[C:12](=[CH:13][CH:14]=[C:6]([S:3](=[O:5])(=[O:4])[NH:2][CH3:1])[CH:7]=3)[NH:11][C:10]2=[O:15])[NH:23][C:22]=1[CH3:34])=[O:20])[CH3:17]

Participants

3

Reactant 2

HCID 10176909N-methyl-2-oxoindoline-5-sulfonamideHCID 542399104-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 69770172HCID 69770172, compoundYield 40.5%

Procedure

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (113 mg, 0.5 mmol) was condensed with 4-(3-dimethylamino-propyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (133 mg) to give 96 mg (40%) of the title compound.

Sources & evidence

ORD record
ord-23344517b85b48fbab72d6cf734b6990
Source dataset
uspto-grants-2003_03
Patent number
US06531502B1

Reaction notes

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