HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Indole-2-carboxaldehyde | HCID 96389 | — |
| Reactant | 4-Methyl-1,3-dihydro-2H-indol-2-one | HCID 12579382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one | HCID 54207197 | — |
Reaction Steps
A mixture of 4-methyl-2-oxindole (147 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06531502B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-2434a7e991814763b2bfe89c08021f9d |
| Source note | uspto-grants-2003_03 |