Hydrochloric Acid → HCID 10293123, compound

Participants

Reaction Steps

A solution of 5-(2-amino-ethanesulfinyl)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one (from Example 42 above) (20 mg, 0.06 mmol) in DMF (approximately 2.5 mL) was treated with aqueous HCl with vigorous stirring. The solution was lyophilized and the residue was dissolved in methanol, filtered and concentrated. The resulting material was further purified by precipitation out of MeOH/CH2Cl2 (3:1) with excess of pentane to give 5-(2-amino-ethanesulfinyl)-6-fluoro-3-(1H-pyrrol-2-yl)-1H-benzo[cd]indol-2-one hydrochloride salt as an orange solid. (Yield 19 mg, 77%).

Provenance & Evidence