4-Methoxycarbonylphenylboronic acid → Methyl 4-(3-{[(3-Methoxy-5-Methylpyrazin-2-yl)[(2-Methylpropoxy)carbonyl]aMino]sulfonyl}pyridin-2-yl)benzoate

Participants

Role	Name	HCID	Charge
Reactant	4-Methoxycarbonylphenylboronic acid	HCID 2734369	—
Reactant	Isobutyl (2-chloropyridin-3-yl)sulfonyl(3-methoxy-5-methylpyrazin-2-yl)carbamate	HCID 11015197	—
Product	Methyl 4-(3-{[(3-Methoxy-5-Methylpyrazin-2-yl)[(2-Methylpropoxy)carbonyl]aMino]sulfonyl}pyridin-2-yl)benzoate	HCID 22325614	—

Reaction Steps

reaction of 2-chloro-N-isobutoxycarbonyl-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) in the presence of a source of fluoride ion and under aqueous conditions to give N-(isobutoxycarbonyl)-2-(4-methoxycarbonylphenyl)-N-(3-methoxy-5-methylpyrazin-2-yl) pyridine-3-sulfonamide;

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06531605B1
Source dataset	uspto-grants-2003_03
ORD ID	ord-f8381ba5fee64896af01a430891a135f
Source note	uspto-grants-2003_03