HCID 21877263, compound → HCID 21877604, compound

HRID 1861063Notes

Reaction equation

HRID 1861063 reaction equation
[CH:1](/[C:9]1[C:17]2[CH2:16][CH2:15][C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][C:12]=2[NH:11][N:10]=1)=[CH:2]\[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C1C2C(=CC=CC=2)CCC1.[Pd]>[CH:1](/[C:9]1[C:17]2[C:12](=[CH:13][C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:15][CH:16]=2)[NH:11][N:10]=1)=[CH:2]\[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 21877263HCID 21877263, compound

Product 1

HCID 21877604HCID 21877604, compoundYield 55%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8404TetralinSolvent

Conditions

Temperature
155 °C

Procedure

A suspension of 3-(E-styryl)-6-phenoxy-4,5-dihydro-1H-indazole (200 mg. 0.64 mmol) and 5% Pd/C (200 mg) in 10 mL of tetralin was heated at 155° C. for 18 h. The catalyst was removed by filtering the hot solution and washed with THF, EtOAc and MeOH. The filtrate was concentrated under reduced pressure and the residue was chromatographed on silica gel eluting hexanes/EtOAc (2:1) to provide 3-(E-styryl)-6-phenoxy-1H-indazole as an off-white solid (110 mg, 55%). 1H NMR (DMSO-d6) δ 6.96 (s, 2H), 7.10 (d, 2H, J=7.7 Hz), 7.20 (t, 1H, J=7.1 Hz), 7.30 (t, 1H, J=7.1 Hz), 7.44 (m, 6H), 7.71 (d, 2H, J=7.5 Hz), 8.20 (d, 1H, J=9.2 Hz), 12.90 (s, 1H). Anal. Calc. for C21H16N2O.0.1H2O: C, 80.28; H, 5.20; N, 8.92. Found: C, 80.20; H, 5.21; N, 8.93.

Workup

  1. customThe catalyst was removed
  2. filtrationby filtering the hot solution
  3. washwashed with THF, EtOAc and MeOH
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe residue was chromatographed on silica gel
  6. washeluting hexanes/EtOAc (2:1)

Sources & evidence

ORD record
ord-cdacf5415b7e42d38d4b3a6daef1edff
Source dataset
uspto-grants-2003_03
Patent number
US06531491B1

Reaction notes

Loading…