Trifluoroacetic acid methylene chloride → HCID 18623633, compound

HRID 1861259Notes

Reaction equation

HRID 1861259 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:32])[CH:14]([NH:16][C:17](=[O:31])[C:18]1[CH:23]=[C:22]([Cl:24])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[CH:20][C:19]=1[O:29][CH3:30])[CH3:15])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[C:26]([NH:25][C:21]1[C:22]([Cl:24])=[CH:23][C:18]([C:17]([NH:16][CH:14]([CH3:15])[C:13]([N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:6]([OH:7])=[O:5])=[O:32])=[O:31])=[C:19]([O:29][CH3:30])[CH:20]=1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 54228308HCID 54228308, compound

Product 1

HCID 18623633HCID 18623633, compound

Procedure

Prepared from 96c by treatment with TFA/CH2Cl2. After complete reaction, the solvent is removed in vacuo and the residue repeatedly concentrated from toluene. The resulting residue was dried under vacuum to a constant weight.

Workup

  1. customAfter complete reaction
  2. customthe solvent is removed in vacuo
  3. concentrationthe residue repeatedly concentrated from toluene
  4. customThe resulting residue was dried under vacuum to a constant weight

Sources & evidence

ORD record
ord-0c40a4dfc92a4c5781df233e5029110b
Source dataset
uspto-grants-2003_03
Patent number
US06531474B1

Reaction notes

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