HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Benzyl-[1-(4-ethynylphenyl)-cyclopropyl]-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzyl-[-(4-trimethylsilanylethynyl-phenyl)-cyclopropyl]-methylamine | HCID 69548036 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzyl-[1-(4-ethynylphenyl)-cyclopropyl]-methylamine | HCID 22568949 | — |
Reaction Steps
Using General Procedure E; benzyl-[1-(4-trimethylsilanylethynyl-phenyl)-cyclopropyl]-methylamine (Intermediate 131, 80.0 mg, 0.24 mmol) in methanol (5 mL) was treated with potassium carbonate (80.0 mg, 0.59 mmol) and stirred overnight at ambient temperature. The crude alkyne (60 mg, 99%) was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06531599B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-156ebfb252044ee58a46fd71f4cdce67 |
| Source note | uspto-grants-2003_03 |