p-Toluenesulfonic acid → HCID 18620267, compound

Participants

Reaction Steps

5.1 g (0.01 mol) of bis(5-cyclo-hexylidene)-7-tert-butyl-3-hydroxy-benzofuranone (U.S. Pat. No. 5,614,572, compound 107, Table 1), 8.75 g (0.046 mol) of p-toluenesulfonic acid and 9.8 g (0.046 mol) of 4-acetamino-tetramethylpiperidine (TEMPO) are stirred in 60 ml of dichloromethane at room temperature for 48 hours. The yellow solution is then washed with 50 ml of 5% hydrochloric acid and 4×50 ml of water, dried over magnesium sulfate and concentrated to dryness by evaporation. The residue is dissolved in 100 ml of toluene, and the solution is heated under reflux for 1 hour and then concentrated by evaporation again, yielding 5 g of the abovementioned compound.

Provenance & Evidence