Dibromomethane → Diethyl bromomethylphosphonate
Reaction equation
[P:1]([O:8]CC)([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4].[Br:11][CH2:12]Br>>[CH2:3]([O:2][P:1]([CH2:12][Br:11])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:4]Participants
3
Procedure
(according to P. C. Crofts, G. M. Kosolapoff J. Am. Chem. Soc. 1953, 75, 5738-40) 126 g of triethyl phosphite and 162 g of dibromomethane are heated to 170° C. in an autoclave for 4 hours. Bromomethylphosphonic acid diethyl ester may be isolated in moderate yield from the reaction mixture by distillation (b.p.: approx. 50° C., 7 Pa (0.05 Torr)). A second fractional distillation was then performed.
Sources & evidence
- ORD record
- ord-cccb1003c0a14d6da134381a69ddf256
- Source dataset
- uspto-grants-2003_03
- Patent number
- US06534489B1
Reaction notes
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