Triethylamine → HCID 93038209, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of 3.0 g of H-Leu-OMe.HCl in 30 mL of dichloromethane was adjusted to pH 8 using triethylamine and cooled at 0° C. Then 3.2 mL of ethanesulfonyl chloride and 2.3 mL of triethylamine were added. After stirring for 16 h at room temperature the reaction mixture was washed successively with 0.5 N hydrochloric acid, water and aqueous 5% sodium hydrogencarbonate and concentrated. The crude product was purified by chromatography on silica gel (eluent: dichloromethane/methanol=9/1 v/v) to yield 3.3 g of EtSO2-Leu-OMe.

Provenance & Evidence